Diabetes is a prevalent metabolic disorder characterized by elevated blood glucose levels due to impaired glucose metabolism. Current therapeutic approaches target enzymes involved in carbohydrate digestion and absorption, such as α-amylase and α-glucosidase, to control postprandial hyperglycemia. In this study, we designed and evaluated 100 zinc-based derivatives of epicatechin as potential inhibitors of these enzymes. Epicatechin, a natural flavonoid found in various plants, has shown promising inhibitory activity against α-amylase and α-glucosidase. By incorporating zinc into epicatechin derivatives, we aimed to enhance their binding affinity and inhibitory potency