To make Endodontic retreatment successful, reentry to the root canal system to remove all filling materials, identification and correction of pathological or iatrogenic defects is a prerequisite. Objective: This study was intended to compare the dissolving efficacy of eucalyptus oil, orange oil and distilled water versus three types of endodontic sealer, Viz.,Endoseal®, NanoSeal -S®, and RC Seal. The dissolution capacity of gutta percha was also studied independently in eucalyptus oil, orange oil and distilled water. Materials and methods: Sixty (60) stainless steel molds were fabricated, where each cement sample was placed to the edge and left to set in the incubator, simulating normal oralconditions for 7 days. Subsequently, the solubility of each cement was analyzed by immersing the samples in eucalyptus and orange essential oil for twelve minutes in a static environment. The solubility of the cement was evidenced by the difference between the weight before and after contact with the oils for 12 minutes, similarly 3 groups of gutta percha of 30 sample size each were kept in oils to check dissolution. Sample data were statistically analysed with the ANOVA test and the post hoc Tukey test. Results: The control group have no significant effect on the pre and post weight of solubility of different sealers used and hence on the mean difference also. The orange oil had better dissolution effects,(p < 0.05). Conclusions: The most susceptible cement was Endoseal sealer, while the least soluble was Nanoseal sealer in all the solvents studied. Gutta percha cones dissolution was more in orange oil compared to eucaluptus oil.