Context: peri-implant strain, cement and screw retained implant Prostheses Aims: To compare peri implant strain generated in implant supported prostheses, cement retained and screw retained, with three different materials, all metal vs porcelain fused to metal vs all ceramic using invitro testing system. Settings and Design: A total of 60 samples of implant supported prostheses were made. 30 for cement retained (10 for all metal, 10 for porcelain fused to metal, 10 for All ceramic) and 30 for screw retained (10 for all metal,10 for porcelain fused to metal,10 for All ceramic) Methods and Material: In a PMMA mandibular model a dummy implant (ADIN), was placed on the right and left side of the region. Simultaneous static load application at central fossae region of both the crowns was administered, of 400 N on each prostheses for a period of 10 seconds using universal testing machine, and peri-implant strains was measured with digital image correlation method. Statistical analysis used: Data were summarised as Mean ± SE. Groups were compared together by two factors (groups x subgroups) ANOVA and the significance of mean difference within (intra) and between (inter) the groups was done by Tukey’s HSD post hoc test. Analyses were performed on SPSS software. Results: Here mean peri implant strain (±SD) generated was found to be highest in All ceramic screw retained implant prosthesis and least in All metal cement retained implant prosthesis respectively. Conclusions: Here we concluded that the Implant design, superstructure material, and load direction significantly affect peri-implant microstrains.