Most pharmacological medications frequently exhibit poor dosage proportionality, significant intra- and inter-subject variability, and limited oral bioavailability when taken orally. It has been estimated that around 40% of innovative medication candidates don't dissolve very well in water. The development of a microemulsion drug delivery system may be the solution to the problem of how well lipophilic drugs work in the body (ME). A microemulsion is an idealised mixture of isotropic oils and surfactants, which may also comprise co-solvents. Microemulsions are also known as nano-emulsions. It is possible to make a fine oil-in-water emulsion on its own by pouring the mixture into the water phase and then gently swirling it around. The movement of the stomach and intestines that occurs during digestion makes it possible for in vivo emulsification to occur. The use of microemulsion is becoming more common and is essential in many different technological domains all over the world. These uses include oil recovery that is more economically feasible, combustion, cosmetics, pharmaceutical, agriculture, metal cutting, lubrication, food, enzymatic catalysis, organic and bioorganic processes, and more.