More than half of individuals with diabetes, mainly T2DM, are undiagnosed; cases are frequently not diagnosed until severe complications appear. However, even early diagnosis is not enough to slow the rise in the incidence of T2DM and its complications. Even in diagnosed patients, the disease’s progression may be accelerated by aggravating factors such as the lack of rigorous glycemic monitoring, under-treatment, inadequate treatment adherence, and omission of lifestyle changes. In addition to the inability of biomarkers to reflect glycemic status accurately. Because early diabetes is largely asymptomatic, many patients are at risk of developing life-threatening complications due to hyperglycemia. In low- and medium-income countries, patients present with an even higher risk of complications due to inadequate healthcare. Irisin, a novel myokine produced in response to physical activity, promotes white-to-brown fat transdifferentiation. The name irisin referred to the ancient Greek goddess Iris, the messenger who delivered (bad) news from the gods. In mice, it has been demonstrated that irisin plays a key role in metabolic regulation, energy expenditure and glucose homeostasis. Since its discovery, it has been hypothesized that irisin may have beneficial effects on chronic diseases such as obesity and type 2 diabetes (T2D), as well as protective effects against cardiovascular risk. However, attempts to reproduce in humans the encouraging findings obtained in animal studies have had conflicting results.