The use of Personal Protective Equipment (PPE), in particular face masks, due to COVID-19 pandemic, has become a common tool used in averting the spread of the virus. The problem of disposing and managing solid waste materials in all countries has become one of the foremost environmental, economical, and social issues. Incineration plants across the world, but the Bio-Medical Waste (BMW) has always been piled in the environment. This paper presents the influence of Bio-Medical Waste ash as fine aggregate replacement on the strength of cement mortar. A control cement mortar mix for 1:4 ratio was made and three cement mortar mixes were made with three different percentages (15%, 25% and 35%). Compressive strength of the Bio-Medical Waste ash for 15% and 25% replacement has shown good results while 35% replacement strength reduced. After paralleling all the experimental test results 15% replacement level is taken as the optimized percentage