Objective: The aim is to investigate the clinical characteristics, outcomes, and management of patients suffering from sepsis acute kidney injury. Methodology: This prospective observational study evaluated the frequency of acute kidney injury in sepsis patients admitted to the general medicine department of a tertiary care hospital between October 2021 and March 2022. These patients underwent laboratory and radiographic examinations. The APACHE II and SOFA scores were computed in addition to the RIFLE risk, injury, and failure categories. Treatment management was closely monitored until the patients were discharged.