Liver cirrhosis is defined as formation of regenerating nodules surrounded by fibrous bands due to chronic liver injury that ends up by liver cell failure and portal hypertension. unlike other complication of liver cirrhosis ,hepatic encephalopathy affect the quality of life of the patient and their family , for the patient frequent readmission and worsening the cognitive performance with each episode and increase dependency on the others. Acute kidney injury is defined as sudden loss of excretory function of Kidney, (AKI) is a part of disorders summarized as ( AKD ) acute kidney disease , in which slow deterioration of kidney function associated with permanent loss of kidney cells and nephrons which can lead to chronic kidney disease (CKD). Acute kidney injury is a common complication associated with liver disease especially decompensated liver disease , and the most common types of AKI occur with liver cirrhosis is the pre renal type and acute tubular necrosis . the pre renal type is more benign and respond to good fluid replacement but the renal type have a bad prognosis and require more specific treatment. Renal dysfunction in patient with chronic liver disease has been called hepato renal syndrome which result from wide spectrum of complication mainly portal hypertension that affect systemic hemodynamics then bile acid nephropathy, coagulopathy-induced bleeding from ischemic Acute tubular necrosis , related glomerular diseases (e.g., immunoglobulin, a nephropathy, hepatitis B and hepatitis C-related glomerulonephritis, cryoglobulinemia, membranoproliferative glomerulonephritis), and other comorbid diseases such as inherited cystic diseases.