Adiponectin is the most abundant adipokine in human blood with a physiological level of 5–30 μL/mL secreted from adipose tissues. There are two kinds of adipose tissue present in humans: white adipose tissue (WAT) and brown adipose tissue (BAT). Adiponectin (also known as Acrp30, GBP-28, apM1, and AdipoQ) is a protein mainly secreted by WAT adipocytes. Other tissues such as human murine osteoblasts, liver, parenchyma cells, myocytes, epithelial cells, and placental tissue show low levels of adiponectin secretion. The main biological functions of adiponectin include enhanced fatty acid biosynthesis and inhibition of gluconeogenesis in the liver. Patients with psoriasis have lower plasma adiponectin levels, which may worsen the severity of their skin lesions. Previous documents revealed that plasma C-reactive protein (CRP) levels are negatively correlated with plasma adiponectin levels, and a significant negative correlation between CRP and adiponectin mRNA levels was also observed in human adipose tissue. However, in subsequent research, adiponectin serum levels were also positively correlated with the sedimentation rate (SR) and CRP levels, which was somewhat puzzling. Previously, the importance of this relationship in the course of psoriasis was unclear, but now it has been demonstrated that plasma adiponectin decreases and CRP increases as metabolic diseases progress. Therefore, the reduction in adiponectin levels is closely related to the occurrence of psoriasis. As an inflammatory factor, CRP participates with various cytokines in the immune response and may play an important role in promoting the development of psoriasis.