Background: Alopecia areata is a type of non-scarring hair loss that impacts hair follicles, nails, and rarely, the retinal pigment epithelium. It typically presents with round patches. Alopecia areata is a disorder of hair follicle-cycling, where inflammatory cells attack the hair follicle matrix epithelium that is undergoing early cortical differentiation ; anagen hair follicles, which are then prematurely induced into the catagen phase. Immune privilege protects organs from potential harm of immune recognition by creating an anergic state that could sometimes tolerate a foreign graft within the tissue . The well-known IP sites are central nervous system, testes, placenta and eyes . Hair follicles are also thought to be immune privileged sites, exactly; the bulge throughout the hair cycle and the bulb in the anagen phase. The most common clinical presentation of AA is patchy AA with the appearance of single or multiple circumscribed patches of scalp hair loss which can either be discrete, isolated or can coalesce with other lesions to form a larger area devoid of hair. The skin within the lesions is smooth, healthy-looking, and intact while sometimes a slight oedema is palpable, but without any erythema or other signs of inflammation.