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ISSN 2063-5346
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An Overview about Cardiovascular manifestations of Inflammatory Bowel Disease

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Mohammed Abd Elraouf Abd Elhamid , Mohammed Elsayed Hamed , Naglaa Ali Khalifa , Sabry Abdel Rahman Tolba
» doi: 10.48047/ecb/2023.12.1.599

Abstract

Inflammatory Bowel Disease (IBD) defines a group of chronic inflammatory diseases that affect mainly the gastrointestinal tract , mainly presenting in two major forms: Crohn’s Disease (CD) and Ulcerative Colitis (UC). The pathogenesis of IBD is not yet fully explained , but it is known to result from the interaction between four major components: an aberrant immune system, genetic factors, environmental triggors, and intestinal microbiota (so , the presence of only one component does not cause the onset of IBD). The main manifestations in IBD are intestinal (abdominal pain, mucoid or bloody stool, rectal bleeding, and tenesmus) and systemic (fever, fatigue, loss of appetite, and weight loss) . IBD can also exhibit a wide range of extraintestinal manifestations (IBD-associated disorders that affect organs that are distant to the digestive tract): hepatobiliary, genitourinary, musculoskeletal, respiratory, ophthalmic, cutaneous, and cardiovascular. Cardiovascular manifestations in IBD can be defined by IBD-associated disorders that affect the cardiovascular system . Cardiovascular manifestations in patients with IBD mostly occur as immune-related consequences and include the following: pericarditis, myocarditis, venous and arterial thromboembolism, left ventricle impairment, arrhythmias and conduction disorders, infective endocarditis, valvulopathy, and Takayasu arteritis.

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