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ISSN 2063-5346
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An Overview about Chronic kidney disease

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Hamed Abdel Aziz Deraz, Nagwa Mohamed Shawky, Ahmed Salah Amin Alallam, Mohamed Saber Mohamed Ateya
» doi: 10.31838/ecb/2023.12.1.472

Abstract

Chronic kidney disease (CKD) is a clinical syndrome secondary to the definitive change in function and/or structure of the kidney and is characterized by its irreversibility and slow and progressive evolution. Another important aspect is the pathology rep-resents a higher risk of complications and mortality, especially cardiovascular-related. An adult patient is identified with CKD when they present, for a period equal to or greater than three months, glomerular filtration rate (GFR) lower than 60 ml/min/1.73 m2, or GFR greater than 60 ml/min/1.73 m2, but with evidence of injury of the renal structure. Some indicators of renal injury are albuminuria, changes in renal imaging, hematuria/leukocyturia, persistent hydroelectrolytic disorders, histological changes in kidney biopsy, and previous kidney transplantation. Albuminuria is defined by the presence of more than 30 mg of albumin in the 24-hour urine or more than 30 mg/g of albumin in an isolated urine sample adjusted by urinary creatinine. The main causes of CKD include diabetes, hypertension, chronic glomerulonephritis, chronic pyelonephritis, chronic use of anti-inflammatory medication, autoimmune diseases, polycystic kidney disease, Alport disease, congenital malformations, and prolonged acute renal disease.

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