Chest wall reconstruction is a complex surgical procedure that aims to restore the integrity of the chest wall after injury or disease. Chest wall reconstruction continues to evolve, with the advent of newer biomaterials and evidence-based surgical approaches aimed at minimizing perioperative morbidity while maintaining functional and physiologic outcomes. Improvements in surgical techniques, critical care, and adjuvant therapies have allowed surgeons to perform more extensive and aggressive surgical resections. However, the resultant defects are often complex and necessitate the use of prosthetic materials and autologous soft tissue rearrangement to restore thoracic skeletal function. The need for a fairly rigid construct to resist paradoxical movement and protect vital organs while allowing physiologic chest excursion has been a longstanding vexing reconstructive challenge. Proline mesh is a synthetic, non-absorbable polypropylene material commonly used in reconstructive surgeries for decades due to its biocompatibility and durability. Proline mesh is a type of surgical mesh that is commonly used in a variety of surgical procedures, including hernia repairs, abdominal wall reconstruction, and chest wall reconstruction. In the context of the chest wall, Proline mesh can be utilized to provide support and stability to damaged or defective areas of the chest wall.