Pediatric bullous skin disorders comprise a diverse group of conditions marked by blister formation on the skin, ranging in size and location. These disorders stem from various causes including genetic predispositions, immune system malfunctions, infections, and medication reactions. The appearance of blisters can be distressing, necessitating precise diagnosis and management strategies. Diagnosis involves a detailed medical history, comprehensive physical examination, and relevant laboratory tests to accurately identify and treat these dermatological conditions affecting children and adolescents. The physical examination is extensive, assessing not only the skin but also hair, nails, and mucous membranes for abnormalities. The classification of lesions into primary and secondary types, based on their origin and subsequent changes due to external factors, is critical for diagnosis. This study synthesizes information from a thorough literature review conducted across multiple databases and manual searches, highlighting the importance of microscopic examination, biopsy, and various laboratory tests in diagnosing skin diseases. It covers genetic disorders like epidermolysis bullosa, autoimmune conditions including bullous pemphigoid, alongside infectious diseases such as Impetigo and fungal infections.