CRISPR-Cas9, the clustered regularly interspaced short palindromic repeat phenomenon associated with cas9 protein, currently accorded with noble laureate accreditation has been referred to as the most versatile and revolutionary genome-editing tool in accordance to its credibility and efficiency by allowing selective perturbation of an individual’s genetic elements and precisely the reverse engineering of mutated genome, responsible for unintended and incurable alterations, surpassing the previously employed tools like zinc finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs) in terms of intuitive work profile and adaptable response. This system is employed by bacteria and archaea to foster adaptive immunity and perpetuate everlasting memory against viral pathogens. Initial acquisition begins with protospacer recognition followed by the involvement of tracrRNA associated with CRISPR RNA duplex and finalized by RNA guided DNA cleavage. Furthermore DNA modification and modulating complex transcriptive arrays has been made facile. While numerating the aptness, it’s scattered across genome editing, eradicating diseases, economical drug development, biotechnology and empirical agricultural advancement.