Pharmacists and nurses play a crucial role in delivering top-quality care to the community and ensuring all patients have access to medication. Pharmacists and nurses have a crucial role in combating the COVID-19 pandemic, regardless of their work environment. This review aims to emphasize the roles of community and hospital pharmacists as well as nurses during the global COVID-19 pandemic. It will clearly demonstrate their contributions in maintaining pharmacy services, supporting other healthcare professionals, and educating patients. Clinical pharmacists-nurses offer direct patient care by overseeing adverse medication reactions, customizing treatment plans, implementing evidence-based practices, and assessing pharmaceuticals in clinical trials. Community pharmacists, the most accessible healthcare providers in the community, enhance awareness of preventive measures, manage medicine supply and demand, offer drive-thru and home delivery services, provide telehealth counseling and psychological support, refer suspected COVID-19 cases, and administer vaccinations when possible.