Social workers, nurses, and pharmacists can mitigate the substantial disparities that have arisen during the COVID-19 pandemic and other comorbidities by incorporating a policy practice framework into their professional responsibilities across diverse health and social environments. The COVID-19 pandemic has resulted in significant transformations in the provision of healthcare, intricate social, behavioral, and economical health emergencies, and a multitude of disparities.We examine the responsibilities of nurses, pharmacists, and social workers in mitigating health comorbidity. According to the research, the program that combines pharmacists and social workers showed a noteworthy decrease in the occurrence of multiple health conditions in the hospital environment.