A 38 year old female presented to the Out Patient Department with the chief complaint of pain over right shoulder since 5 years. The patient had a marked reduction in the range of motion of the right side of the shoulder in all directions. On Computed Tomography scan, features suggestive of marked erosion and destruction involving medial and posterior portion of right humeral head along with glenoid were observed. In the second stage at 8 weeks from the index procedure, a complete removal of necrotic bone followed by placement of iliac crest bone graft to restore the bone stock of the glenoid defect. A stemmed antibiotic cement spacer was applied to the humeral head defect. A right sided unilateral platform stem hemiarthroplasty procedure was planned. The patient was given adequate antibiotics and physiotherapy was initiated. At 6 months follow up, patient had achieved full right shoulder range of motion and could resume her daily activities.