Objective: For exploring the positive self-behavior intervention on the scores of facial pain scale (FPS), fibrinogen (FBG) and hematocrit (HCT) in migraine patients. Method: 80 migraine patients who were treated at our hospital from January 2022 to December 2022 were retrospectively selected from the hospital records. They were separated into groups. The control group (n=40) received routine nursing intervention, while the research group (n=40) received positive self-behavior intervention based on the control group. The health behavior, pain perception, FBG, and HCT levels of the patients participating in the experiment were compared. Results: Before the intervention, there was no statistically significant difference in health behavior scores, FPS scores, FBG, and HCT levels among the patients participating in the experiment (P>0.05); After intervention, the research group showed higher scores in regular medication, dietary norms, quantitative exercise, and pain control relative to the control group, with statistically significant disparities (P<0.05); The FPS score of the research group was below that of the control group, and the disparity was statistically significant (P<0.05); The levels of FBG and HCT in the research group were lower than those in the control group, and the disparity was statistically significant (P<0.05). Conclusion: Positive self-behavior intervention promotes migraine patients for improving and maintaining their own healthy behavior, reduce pain sensation, and maintain normal levels of FBG and HCT indicators