Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Incidences of cutaneous adverse drug reactions (CADRs) have showed increase in trend due to the indiscriminate and irrational use of medications and sometimes its life threatening as well. The objectives of the study were to identify different clinical spectrum of CADRs and to determine the causative agents, their severity and preventability. A cross sectional, descriptive study was conducted over a period of 1 year and 4 months f rom 1s t of August 2019 to 31s t November 2020, patients with various CADRs that reported to the Department of Dermatology were recorded. Causality, Preventability and Severity were assessed. A total of 322 patients were included in the study. Male preponderance (53.41%) was seen with maximum 22.67% in 18-35yrs age group and females (46.58%) showing maximum no 20.49% in 18-35 years age group. Analysis of patterns revealed that, Maculo Papular Rash (MPR) (29.50%) was the most common presentation among all CADRs followed by fixed drug eruption in 17.39%, SJS-TEN overlap syndrome in 13.04%, drug hypersensitivity syndrome (DHS) 7.76%, acneiform eruption 5.27%, Urticarial Vasculitis 4.03% comprised of majority of the cases. Most frequently involved drug classes were Antibacterial agents (28.74%) followed by non-steroidal anti-inflammatory agents [NSAIDs] (15.47%), Drugs acting on central nervous system (12.28%), Antiviral agents (11.05%) and Antitubercular drugs (7.86%). In accordance to WHO-UMC causality assessment scale classifies 55.12 % as probable, 40 % as possible and 4.87 % as definite. The most common suspected drug incriminated in various drug interactions is Antibacterial agents (27.92%) followed by NSAIDs (15.03%).