A novel simple, and accurate RP-HPLC technique was established for the simultaneous quantification of pharmaceuticals in a bilayer tablet comprising Hydrochlorothiazide, Amlodipine. and Telmisartan. Good chromatographic separation was accomplished in the isocratic mode using 0.022M monobasic sodium phosphate dihydrate phosphate with 2ml of triethylmine 1L adjusted with phosphoric acid tp a PH of 6.0 buffer and Acetonitrile (60:40) as the mobile phase, Intersil C18 (250 mm 4.6 mm id. 5 um particle size) column as the stationary phase, and a flow rate of 1.0 millilitre per minute at a detection wavelength of 257 nm. The reported periods of retention for hydrochlorothiazide, amlodipine, and telmisartan were 4.025 minutes, 7.486 minutes, and 14.084 minutes, respectively. As per ICH recommendations, this procedure has been verified. The method delivers good resolution between the medicines with low retention time. The validation parameter findings show that the suggested method is linear, exact, accurate, precise, robust, specific, and selective. As a consequence, the suggested study's findings support the notion that the established approach is an effective strategy for simultaneously estimating the dosages of Hydrochlorothiazide, Amlodipine, and Telmisartan in tablet form. The proposed study's findings support the idea that the approach devised is an accurate approach for simultaneously estimating the concentrations of Hydrochlorothiazide, Amlodipine, and Telmisartan in a bilayer tablet dosage form.