Background: Hesperetin is a cholesterol lowering flavonoid, derivative of hesperidin. It is used in treatment of various ailments pertaining to its medicinal properties like neuro protective, anti-oxidant and immune boosting properties. Harpagoside is a terpene glycoside reported to produce anti diabetic activity by binding to the pyridoxal phosphate site of glycogen phosphorylase-a and have potent anti- rheumatic, anti-inflammatory and analgesic effects as well. Hesperetin and Harpagoside are present inmethanolic flower extract ofPhlogacanthus thyrsiformis (Roxb. ex Hardw.) Mabb