Introduction : Lignocaine is the most commonly used local anesthetic agent in oral and maxillo facial surgery especially in minor oral surgical procedures such as surgical removal of impacted mandibular third molars. Loss of anesthesia during extraction of mandibular 3rd molars has been reported even though right anesthesia technique and proper dose used. This was the back ground of this study. Aim : Local anesthetics form the backbone of intra-operative and postoperative pain control. Conventional lignocaine has many disadvantages which have been compared with articaine and bupivacaine. Since there are few studies comparing articaine, bupivacaine with lignocaine, we have selected this study to evaluate the anesthetic efficacy and safety in surgical removal of impacted mandibular third molars.