In this study, the association between anti-androgen therapy and the risk of SARS-CoV-2 infection in men with prostate cancer was studied, through analyzing the medical records of 4,532 men with prostate cancer that were collected from electronic medical records., including 1,524 who were receiving anti-androgen therapy. The results showed that men receiving anti-androgen therapy had a lower risk of SARS-CoV-2 infection compared to those not receiving the therapy. The data suggested that anti-androgen therapy may have a protective effect against SARS-CoV-2 infection in men with prostate cancer. This study hypothesized a possible pathway to be investigated for the mechanism of androgen deprivation therapy in reducing the risk of SARS-CoV-2 infection through AR\TMPRSS2\ACE2 with explanation of the idea behind, however an experimentation of this pathway is required to confirm or exclude the hypothesis.