Exposure to noise stress is inevitable and stressful experience can alter the neuroendocrine axis which is detrimental to the neurobehavior of the animal. To date, there is no medication to combat this environmental stressor. Targeting herbal remedies with potent antioxidative and anti-apoptotic effects could help narrow down the therapeutic approach against this illness. To induce phschology stress, animals were exposed to noise stress (100 dB/4 h/day) for 30 days. This study showed that elevated corticosterone level at 100dB indicates that noise is a psychological stressor. Corticosterone can have rapid or long-term influences on neural circuits and can significantly influence behavior. In the open-field test, locomotor function of the animals was observed via increased rearing and decreased peripheral and central ambulation. Increased immobilization is a sign of despair and depressive behavior. The influence of increased dopamine, norepinephrine, and serotonin level when exposure to noise could have altered the emotional behavior of the animal. On the other hand, increased expression of Bcl-2 by 53.39% when compared to Bax in the noise-exposed group indicates the capability of the animal to stress response. Therapeutic strategies of S. dulcis via their antioxidative and anti-apoptotic properties can act as an antidote for this pervasive environmental stressor.