Around 50 million people in the world are affected by Vitiligo which is a chronic inflammatory cutaneous disorder. Vitiligo is not a life-threatening disease, it causes disfigurement in the appearance leading to psychological harm to patients. Moreover, vitiligo favours vulnerability to other diseases like arthritis, hyperthyroid's, diabetes and lupus erythematosus. Siddha system is a traditional system that has originated in India since 4000 years ago with unique treatment methods and herbomineral formulations for various skin diseases and autoimmune diseases. The present study is aimed to execute the in-Silico computational studies of phytoconstituents of Siddha formulation Karbogi pasai that has been indicated for the treatment of vitiligo(Venpadai).The study was aimed to find the lead molecules in the herb Karbogi pasai a Siddha formulation to bind with specific amino acid residues in the tyrosinase enzyme, which helps in melanogenesis, to enhance tyrosinase activity and improve hypopigmentation medical conditions like vitiligo. Docking analysis of 11 phytoconstituents in Karbogi pasai was performed using AutoDock program. The lead compound Isovitexin was found to have the strongest binding affinity against tyrosinase. Bavachinin had the lowest Ki value and Pantothenic acid had the strongest electrostatic interaction. Overall, the study found potential antivitiligo effects of the herb's phytoconstituents.