Erythrasma is an intertriginous infection caused by Corynebacterium minutissimum that is most common among patients with diabetes and among people living in warmer climates.The aim of the present study is to explore antibacterial activity of the plants Cyperus rotundus tuber, Michelia champaca flower bud and Clerodendrum inerme leaves against Corynebacterium minutissimum (ATCC 23348). The ethanol extract of the selected plants was subjected to preliminary phytochemical analysis and HPTLC analysis. The antibacterial effect of the ethanol extract of the plants was evaluated against Corynebacterium minutissimum using agar well diffusion, disc diffusion method. Minimum Inhibitory Concentration (MIC) of Cyperus rotundus tuber was determined using 96 well plate method. In disc diffusion method, the tested plants viz., Cyperus rotundus, Clerodendrum inerme and Michelia champaca at higher concentration (100µg) showed maximum zone of growth inhibition 12 mm, 10 mm and 11 mm respectively. In well diffusion method, the plants Cyperus rotundus, Clerodendrum inerme and Michelia champaca at higher concentration (200µg) showed maximum zone of growth inhibition 20 mm, 22 mm and 18 mm respectively against Corynebacterium minutissimum when compared with standard. The minimum inhibitory concentration of Cyperus rotundus, Clerodendrum inerme and Michelia champaca for arresting the growth of the tested organism was found to be 63 µg/ml. The phytochemical screening demonstrated the presence of different types of compounds like alkaloids, terpenoids, tannins, glycosides, saponins, phenolic compounds, proteins and flavonoids which may contribute for the antimicrobial action of the above medicinal plants and can be developed into safe and effective topical herbal formulation for the management of erythrasma