The aim of this study is to study the fracture union and soft tissue healing of infected nonunion of long bones using antibiotic impregnated intramedullary nails. Methodology: This is a retrospective study of 40 patients with infected nonunion treated with antibiotic cement coated intramedullary nail at Raichur institute of medical sciences, Raichur and Suraksha Hospital, Raichur from 2014 September to 2022 September. All the patients selected for the study were examined according to protocol, clinical examination and radiological investigations were done. Antibiotic cement impregnated intramedullary Kuntscher’s K nail was used for femur and bent K nail and V nail was used for tibia. The outcome of procedure evaluated with respect to infection control, bony union, limb length discrepancy. Results: Infection control and union was achieved successfully in 36 cases (90%) out of 40. Out of these, 14 patients (35%) had union without need for exchange interlocking nailing, 22 patients (55%) underwent exchange interlocking nailing after infection control to achieve union. 4 patients (10%) did not achieve union and had persistent infection in the form of discharge with 2 among them (Tibia) insisted for below knee amputation. Conclusion: ACIIMN is a effective way to control infection and achieve union of fracture simultaneously. This procedure has good patient compliance, safe, cost effective, and easy way without need of expert hands when compared to traditional surgeries like ilizarov’s external fixators for nonunion of tibia and femur.