An antibiotic is a naturally occurring semi-synthetic or synthetic substance used to treat both external and internal infections by destroying or inhibiting the development of pathogenic microorganisms. To maximize benefits and minimize risks, medication prescriptions must be completely rational and economic. But nowadays serious morbidity and mortality occur due to inappropriate or irrational prescriptions of antibiotics, which also leads to antibiotic resistivity, adverse reactions and economically costly. In this study, we have clinically assessed a 58-year-old adult patient for their recommended treatment through ward-round monitoring. By means of clinical pharmacist intervention, the expected occurrence of ADR is prevented which provokes the rational use of Antibiotic.