The increase in the number of diseases that threaten human health in the world causes the need to create new pharmacological drugs to expand year by year. In this regard, the use of natural compounds of plants and their synthetic analogues in the field of pharmaceuticals opens up wide opportunities. In this study the antimicrobial activities of the extracts obtained from 16 endemic plants belonging to the Asteraceae against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) and yeast (Candida albicans) were studied. According to obtained results, ethyl alcoholic extracts were more active compered low polar solvents extracts. Moreover, Achillea filipendulina, Ligularia macrophylla, Artemisia leucodes, Artemisia annua, Erigeron canadensis, Handelia trichophylla, Lactuca sp., Onopordum acanthium and Tragopogon malicus extracts showed different levels of activity.