Phenols and flavonoids present in Marchantia paleacea extract have been analysed for their involvement in antimicrobial activities associated to the plant. Literature provides ample leads of the potential utilisation of phenols and flavonoids as potent antimicrobials. Many researchers have deciphered the role of quercetin as an antimicrobial agent. Extract was prepared in 80 % ethanol by soxhlet extraction. The antimicrobial activity was tested using disc diffusion assay against Salmonella typhimurium, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa along with the determination of minimum inhibitory concentration (MIC). The study reflects that Marchantia paleacea extract shows promising antimicrobial activity against Salmonella typhimurium and Staphylococcus aureus.