Leukocyte-platelet-rich fibrin (L-PRF) is a type of platelet concentrate that was developed by Dr. Joseph Choukroun in the early 2000s. It is classified as second-generation platelet concentrate1. In a variety of procedures, including extraction socket preservation, periodontal surgery, implant placement, and sinus augmentation, the utilization of L-PRF in dentistry and oral surgery has demonstrated promising results. It lacks any natural antibacterial properties. Therefore, when antibiotic treatment is required to control or prevent infection, L-PRF alone cannot substitute for antibiotics. In some cases, L-PRF can be used in conjunction with antibiotic treatment. L-PRF, for instance, can be used in conjunction with antibiotics during oral surgery to support tissue regeneration and healing following the administration of the appropriate antibiotics to control infection. While antibiotics target and eliminate bacteria, the growth factors and regenerative properties of L-PRF can aid in tissue repair.