Antimicrobial drugs are facing a significant problem as a result of the sharp rise in endodontic infections that are drug-resistant. The urgent need to create new control agents is highlighted by the inability of the strongest medicines to eradicate "superbugs." Antimicrobial peptides (AMPs), a rising class of natural and synthetic peptides with a wide range of targets including viruses, bacteria, fungi, and parasites, are reviewed here along with recent advancements in the field.