Ethanol extracts of selected plants have exhibited significant gastroprotective activity. The ethanol extract of cucurbita pepo at a dose of 200 and 300 mg/kg b.w has showed significant gastroprotective activity than ethanol extract of benincasa hispida at a dose of 200, 300mg/kg b.w. Gastroprotective action of certain phytoconstituents like flavonoids, alkaloids, Tannins Have been well documented in the literature. The above mentioned phytoconstituents alone or in combination may be resposible for the gastroprotective activity of the selected plants.