Diabetes mellitus is a potentially morbid condition affecting a large number of people around the world. Animal model of diabetes is vital for the understanding of progression of various aspect of the disease and its pathogenesis and its cure by use of new therapeutics. In the present study the antioxidant and anti-diabetic potential of Zinger root powder (ZRP) was evaluated in streptozotocin induced diabetic rats (STZ). Diabetes in rats were induced by administering streptozotocin of 45 mg/kg of body weight 15 to overnight fasted rats. ZRP 100 mg/kg of body weight was orally administered to group C and Pioglitazone to group D at a dose of 20 mg/kg of body weight for 6 weeks respectively for six weeks. Lipid peroxide levels were also measured in normal, diabetic and treated animals. ZRP treated rats showed significant decrease in biochemical parameters like blood sugar level (BS), triglycerides (TG), and Malondialdehyde (MDA) levels as compared to diabetic rats. However, antioxidant activity was observed low in diabetic groups as compared to the healthy control groups, which was ameliorated by treatment of ZRP. On the basis of our results we obtained from the study we conclude that ZRP not only useful in controlling the blood sugar level but are also helpful against streptozotocin-induced oxidative toxicity by strengthening the antioxidant potential.