Sintering refers to bonding adjacent powder particles together or bonding particles in a compact using heat or solvents. This study applied sintering to develop controlled-release systems for vitamin B2 (riboflavin) using response surface methodology. Pre-compression and post-compression parameters were evaluated and found to be satisfactory. Ethylene vinyl acetate (EVA) 15 was used as the release-controlling polymer. Among three models, a quadratic model was suggested for the T90, floating lag time, and floating time responses, which were found to be 115.24, 101.09 and 86.28 respectively, indicating the models were significant. The ideal values for the selected variables as recommended by the Design Expert® 12 software were 33.78 mg of EVA 15, 7.92% by weight of sodium bicarbonate based on tablet weight, a sintering temperature of 60.47OC, and a sintering exposure time of 4.5 hours. The optimized formulation showed 103 seconds floating lag time, 11.8 hours floating time, and 10.9 hours T90, following zero-order release kinetics with a non-Fickian diffusion mechanism.