Carvedilol drug, is poorly water-soluble and show low has oral bioavailability. Solubility enhanced of low water soluble drug enhanced by solid dispersion method. Method:-Design expert-11 software used to enhance the solubility of poorly water soluble drug carvedilol by solid dispersion techniques. Using central composite designs(CCD) to study the effect of independent variables on solid dispersion of carvedilol and Nine formulations prepared by solvent evaporation and fusion method using different natural and synthetic polymers Hydroxy-propyl methylcellulose (HPMC), Locust bean Gum(LBG) , PEG 6000 (polyethylene glycolate) 6000 and sodium starch glycolate . Prepared formulation evaluation check by solubility, stability, Percentage yields, dissolution rate studies and characterized by Scanning electron microscopy (SEM), Powdered X-ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-red (FTIR).