In the current investigation, a statistical experimental design was used to create an isocratic RP-HPLC method for the simultaneous quantification of dapagliflozin and metformin in bulk and tablet dosage form. Acetonitrile concentration, buffer pH, and flow rate were used as three independent design variables. To thoroughly analyse the effects of these independent elements and analyse the response surface technique, Central Composite Design (CCD) was utilised. Derringer's desirability function was used to simultaneously optimise these three replies. ACN: Menthol (40:40:20) %V/V (pH-2.6) as the mobile phase and a flow rate of 1.0ml/min were the ideal test conditions. In order to verify the optimised procedure's specificity, linearity, accuracy, and precision, it was verified in accordance with ICH requirements.