This study's main goal was to find out how the coating polymers Eudragit S100 and HPMC K100M, as well as coating level conditions, affected the quality characteristics of pellets formulated using a quality by design (QbD) methodology.The drug pellets of rifaximinwere developed by powder layering technology. The time it took for 90% of the drug to be released from the coated pellets was assessed together with the rate of drug release of rifaximin.Additionally, differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy were used to examine the thermal and spectroscopic properties, as well as the