Healthcare-associated infections (HAIs) persist as a persistent problem for patients in acute hospital settings. To effectively prevent and manage Healthcare-Associated Infections (HAIs), it is necessary to adopt a collaborative approach that motivates all healthcare personnel to assume responsibilities and actively participate. Medical professionals, including doctors and nurses, will be educated on the most effective way to execute the essential elements of Infection Prevention and Control. These recommendations are based on the thorough examination of evidence by a panel of experts in this field. This document presents a practical set of requirements for organizations, structures, and professionals to improve the quality and safety of care in relation to infectious risk. These requirements are based on independent suggestions, clinical experiences, evidence-based practices, and literature review. The aim is to protect the patient, facilities, and healthcare providers by using various strategies.