To evaluate the effect of periodontal therapy on frequency of drug and to assess the effect of interventions on periodontal pocket depth, loss of attachment, gingival status and plaque accumulation of asthmatic patients. Materials and methods: A sample of 45 asthmatic patients aged 30-60 year and fulfilled the eligibility criteria was randomly selected from the OPD of Kothiwal Dental College and Research centre. All of the 45 patients will be randomly divided into 3 equal groups. Group A (n=15): patients was undergo scaling, was advised to regularly use 0.12% mouthwash (once daily) and brush (twice daily). Group B (n=15): patients was advised to regularly use 0.12% mouthwash (once daily) and brush (twice daily). Group C (n=15): patients was advised to brush (twice daily). Results All of the 45 participants completed the study. Statistically significant difference was found between GI, PI and PPD scores before and after intervention in group I (p < 0.001), and group II (p< 0.05) only and the differences among the groups were found to be statistically significant for FOD and ND after 1 and 3 months of intervention. On further analysis (post-hoc Turkey for multiple comparisons), group I was found statistically significant with group III after 1 month of intervention whereas group I was found statistically significant with group II and group III after 3 months of intervention. Conclusion : The present study concludes that nonsurgical periodontal therapy can effectively decrease severity of asthma in asthmatic patients . Preventive periodontal regimens for asthmatic patients should be sufficiently intense and sustained so as to eliminate periodontal inflammation. Future more randomized controlled trials should be conducted to better test the hypothesis of this important association, thereby increasing knowledge in this area and also further clarifying the association between the two diseases