Postpartum depression (PPD) is a common and serious mental health issue that affects many women after childbirth. Nurse-led interventions have been increasingly recognized as effective approaches in managing PPD due to their holistic and patient-centered care. This review article aims to assess the effectiveness of nurse-led interventions in managing postpartum depression by synthesizing and analyzing existing literature on this topic. Through a comprehensive review of studies published in the past decade, this paper examines the various nurse-led interventions employed in the management of PPD, such as cognitive-behavioral therapy, psychoeducation, and support groups. The review also explores the impact of these interventions on maternal mental health outcomes, including depressive symptoms, anxiety levels, and overall well-being. Furthermore, this article discusses the role of nurses in providing emotional support, education, and counseling to women experiencing postpartum depression. The review highlights the importance of early detection and intervention in preventing the escalation of PPD symptoms and improving maternal and infant outcomes. Additionally, the paper addresses the challenges and limitations associated with nurse-led interventions in managing postpartum depression, such as resource constraints, training needs, and cultural considerations. By synthesizing the current evidence, this review aims to provide insights into the effectiveness of nurse-led interventions and offer recommendations for future research and clinical practice in this area.