Vaccination and immunization programs play a crucial role in preventing infectious diseases and promoting public health. Nurses and midwives are frontline healthcare professionals who are instrumental in the success of these programs. This review article aims to assess the vital role of nurses and midwives in promoting vaccination and immunization programs worldwide. The article explores the various responsibilities and contributions of nurses and midwives in educating the public about the importance of vaccinations, administering vaccines, monitoring vaccine safety, and addressing vaccine hesitancy. Additionally, the review discusses the challenges faced by nurses and midwives in promoting vaccination programs, such as vaccine misinformation, resource constraints, and vaccine delivery barriers. Strategies to enhance the involvement of nurses and midwives in vaccination and immunization programs are also examined, including training programs, collaboration with other healthcare professionals, and community engagement initiatives. Furthermore, the review highlights the impact of nurse-led vaccination campaigns on increasing vaccine uptake and reducing vaccine-preventable diseases. Overall, this article underscores the critical role of nurses and midwives in advancing vaccination and immunization efforts globally and emphasizes the need for continued support and recognition of their contributions in public health initiatives.