Background. Despite its high prevalence, anemia often does not receive proper clinical attention, and detection, evaluation, and management of iron deficiency anemia and iron-restricted erythropoiesis can possibly be an unmet medical need. A multidisciplinary panel of clinicians with expertise in anemia management convened and reviewed recent published data on prevalence, etiology, and health implications of anemia as well as current therapeutic options and available guidelines on management of anemia across various patient populations and made recommendations on the detection, diagnostic approach, and management of anemia. The available evidence confirms that the prevalence of anemia is high across all populations, also effect in diminished quality of life, and increased risk of morbidity and mortality, and it is a modifiable risk factor of allogeneic blood transfusion with its own inherent risks. Anemia is a condition in which the number of red blood cells and consequently their oxygen-carrying capacity is insufficient to meet all the body’s physiologic needs which are vary with a person’s age, gender, altitude, smoking and different stages of pregnancy. Aim of the study: To assessment Knowledge about general anemia signs and symptoms among adult patient attending at Primary Health Care, Makkah Al-Mokarrama, Saudi Arabia 2022. Methods: across-sectional study was conducted at Makkah primary healthcare centers among among adult patient attending at Primary Health Care who visited clinic for routine follow-up were selected through convenience sampling technique. A questionnaire filled out by the researcher through an interview with the adult patient was utilized for data collection. Results: most of the participants (41.0%) were in the age group >30 years. Regarding the marital status the majority of participant married were (73.0%). Regarding educational level the majority of participant are Secondary education were (45.0%) also regarding Nationality the majority of participant are Saudi were(77.0%). Regarding the Occupation the majority of participant Government/private employed were (42.0%). Conclusion. Anemia is a risk factor for major morbidity and operative mortality in adult . This finding is confirmative of the role of preoperative anemia in determining adverse events in major non operations. In internal medicine setting adult patients are characterized by multi morbidity and poli-pharmacologic treatments, which might affect the erythropoietin compartment, contributing to anemia and iron deficiency.