Objective: To determine the hyperlipidemia frequency in cases of acute pancreatitis Place and Duration of Study: This was a retrospective study conducted at Shaikh Zayed Hospital, Lahore from August 2022, to January 2023. MATERIAL AND METHODS: Inclusion criteria encompassed patients aged 18 and above, with a confirmed diagnosis of acute pancreatitis based on clinical symptoms, radiological findings, and laboratory results. Exclusion criteria included a history of chronic pancreatitis, pre-existing hyperlipidemia, and incomplete medical records. Demographic information, clinical history, and laboratory results, including lipid profiles (total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein), were extracted from electronic health records. The severity of acute pancreatitis was assessed using established criteria (such as the Ranson criteria or the Atlanta classification). Data were analyzed using SPSS version 22.0. RESULTS: The mean age of the population was 56.3±3.1 years. The gender distribution showed a slight male predominance (53.1%). Among lifestyle factors, the majority were non-smokers (68.6%), while 31.4% were smokers. Additionally, 52.6% were non-drinkers, and 47.4% were drinkers. In our study of 175 patients with acute pancreatitis, 34.3% exhibited hyperlipidemia, marked by elevated levels of total cholesterol in 25.7% of cases and increased triglycerides in 20.0%. Notably, 11.4% of patients presented with elevations in both total cholesterol and triglycerides. In the mild/moderate group, 20.0% of patients had concurrent hyperlipidemia, contrasting with 80.0% in whom hyperlipidemia was absent. CONCLUSION: Our study on the frequency of hyperlipidemia in 175 patients with acute pancreatitis provides valuable insights into the prevalence and associations of this metabolic disorder in the context of pancreatic inflammation.