Post-endodontic pain is defined as the sensation of discomfort after endodontic treatment. The present study was conducted to compare intracanal cryotherapy and curcumin as a final irrigant in reducing post endodontic pain in primary teeth. Materials & Methods: 60 primary teeth of age 3-8 years requiring pulpectomy of both genders were randomly divided into three groups. Group I was intracanal cryotherapy using 2.5°C cold saline, group II was curcumin irrigant, and group III normal saline. Subjects were asked to rate the severity of their postoperative pain on the visual analog scale before, immediate postoperative after wearing of local anesthetic effect, and 24 hours after the procedure. Results: Group I had 11 males and 9 female teeth, group II had 8 males and 12 female teeth and group III had 13 males and 7 female teeth. The mean VAS before treatment in group I, II and III was 6.2, 6.3 and 6.1 respectively. The mean VAS post- operatively was 4.2, 5.0 and 5.7 and after 24 hours was 1.7, 2.4 and 2.8 respectively. The difference was significant (P< 0.05). Conclusion: Curcumin irrigant with its anti-inflammatory properties is a better alternative as a final irrigant for reducing postoperative pain in primary teeth. Cryotherapy can be a straightforward, cost-effective, and nontoxic treatment option for the management of postendodontic pain.