Objective: The present study is aimed to evaluate the medication safety of fixed dose combination drugs at a tertiary care hospital. Methodology: It is a prospective observational study conducted in inpatient setting. The data collected in pre design data collection form, who are assessed for the period of six months. Hospitalized patients who were taking at least one fixed dose combination drugs and had a hospital stay of 48 hours were considered for this study. The collected data included demographics, fixed dose combination drugs usage pattern and safety analysis data. The data was compiled in excel and analyzed using Micromedex.