LRTIs, which are widespread infections in people, cause the highest number of deaths globally, with approximately 2.74 million fatalities annually. This study aimed to assess the microbial profile and antimicrobial susceptibility pattern of pathogens isolated from patients with lower respiratory tract infections (LRTIs). A total of 100 respiratory samples were collected from LRTI patients, and the isolated microorganisms were identified using statistical analysis method. The results revealed a diverse microbial profile, being the predominant isolates. The antimicrobial susceptibility pattern demonstrated varying degrees of resistance among the identified pathogens, highlighting the importance of appropriate antibiotic selection for LRTI treatment. This study provides valuable insights into the microbial profile and antimicrobial susceptibility patterns of pathogens associated with LRTIs, aiding in the development of effective treatment strategies and the prevention of antibiotic resistance.