Background: This study was conducted to evaluate the Comparison of Shear Bond Strength of Orthodontic Brackets Using Direct and Indirect Bonding Methods in Vitro and in Vivo. Material and methods: In the in-vitro study, 40 mandibular and maxillary molars were used. Each tooth was put on a cold-cure acrylic block before being separated into two groups: 20 teeth with directly bonded brackets and 20 teeth with indirectly bonded brackets. In the direct method, Transbond XT was used to bond brackets (KND Metal Brackets); in the indirect method, Transbond XT and 3M Transbond adhesive kit were used. Both the adhesive remnant index and the shear bond strength were assessed. 20 patients were used in the in vivo study, 10 of whom had brackets that were directly and 10 of whom had indirect bonds. The six- month assessment of the survival rate was assessed.