knee osteoarthritis is the most common chronic disease which affected the physical and psychosocial status of patients and associated with a high rate of disability and poor quality of life. Aim of study: was to assess physical and psychosocial status among patients with knee osteoarthritis. Design: A descriptive exploratory research design. Setting: The study was conducted at Ain Shams University Hospitals (El Demerdash Hospital), Cairo, Egypt. Subjects: A purposive sample of 129 patients in pre-mentioned setting was enrolled in the study. Tools: Three tools were used for data collection; tool (I) structured interviewing questionnaire that consisted of two parts; part I: demographic data, part II: medical history. Tool (II): Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), Tool (III): psychosocial assessment questionnaire. Results: The current study findings revealed that more than two thirds (61.2%) of studied patients had a high physical needs regarding condition. Moreover, more than two thirds (62%) of studied patients had a high psychological needs. Additionally, more than two thirds (68.2%) of studied patients had a high social needs. Also, there was a highly statistically significant relation between demographic data, chief complain and total level of need among the studied patients. Conclusion: The study findings concluded that more than two-thirds of study subjects had high physical, psychological and social needs. Also, there was a highly statistically significant correlation between total score of physical, psychological and social needs. Recommendations: The current study was recommended that importance of improving patient’s physical and psychosocial status through identify needs and increasing awareness.